Crystal Palace suffered their first defeat since being promoted back to the Women's Super League after Tottenham produced a seven-goal second-half performance against the 10-player Eagles.
Olivia Holdt was the main figure in Tottenham's victory, scoring three times to complete a hat-trick as Palace were overwhelmed after the interval.
The result marks a difficult setback for Palace in their return to the top flight. Tottenham's second-half scoring burst ultimately settled a match in emphatic fashion.
Palace will now look to respond after seeing their unbeaten start since promotion ended against a Spurs side that found the net seven times after half-time.